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intramuscular fat : ウィキペディア英語版
intramuscular fat

Intramuscular fat (or Intramuscular triglycerides ()) is located throughout skeletal muscle. It is responsible for the marbling seen in certain cuts of beef. In humans, excess accumulation of intramuscular fat has been associated with conditions such as insulin resistance and type 2 diabetes. The human immunodeficiency virus (HIV)-lipodystrophy syndrome is associated with over-accumulation of intramuscular fat, which may contribute to AIDS wasting syndrome.
==Diabetes==
Increased IMTG was once thought responsible for increased insulin resistance. However, the discovery that athletes as well as obese individuals have high IMTG levels confounded these findings. Instead, IMTG metabolites, such as diacylglycerol and ceramide are responsible for the insulin resistance. Studies demonstrating the effects of IMTGs show that the mechanism involves the activation of the protein kinase C theta, which promotes the phosphorylation of IRS-1, thereby inhibiting the insulin signaling cascade.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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